{"created":"2023-06-20T13:11:07.814843+00:00","id":191,"links":{},"metadata":{"_buckets":{"deposit":"2ce2edab-2d59-4961-a16a-685b66244b7c"},"_deposit":{"created_by":15,"id":"191","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"191"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000191","sets":["3:9"]},"author_link":[],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"53","bibliographicPageEnd":"69","bibliographicPageStart":"63","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"新島, 富紀枝","creatorNameLang":"ja"},{"creatorName":"ニイジマ, フキエ","creatorNameLang":"ja-Kana"},{"creatorName":"Niijima, Fukie","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"下田, 将司","creatorNameLang":"ja"},{"creatorName":"シモダ, マサカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimoda, Masakazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"吉田, 文","creatorNameLang":"ja"},{"creatorName":"ヨシダ, アヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshida, Aya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"中川西, 修","creatorNameLang":"ja"},{"creatorName":"ナカガワサイ, オサム","creatorNameLang":"ja-Kana"},{"creatorName":"Nakagawasai, Osamu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"丹野, 孝一","creatorNameLang":"ja"},{"creatorName":"タンノ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Tan-no, Koichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"只野, 武","creatorNameLang":"ja"},{"creatorName":"タダノ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Tadano, Takeshi","creatorNameLang":"en"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"Clinical reports have shown that irritable bowel syndrome (IBS) is comorbid with anxiety and stress-related events. The treatment of rapid eye movement (REM) sleep deprivation (REMSD) is a potent stressor in animals. Stress in humans commonly results in gastrointestinal dysfunction, which is characterized by its symptomatology because the etiology is completely unknown. In the present study, we found that intermittent REMSD treatment (20 h/day) for 3 days markedly increased gastrointestinal transit of charcoal meal in mice. The accelerated gastrointestinal transit was significantly inhibited by both diazepam (1 and 2 mg/kg, p.o.) and by a peripheral , μ-opioid receptor agonist loperamide (3 and 10 mg/kg, p.o.), which are clinically used to treat diarrhea-predominant IBS. The ID_<50> values of loperamide in cage-control (CC) mice and intermittent REM sleep deprived mice were 18.14mg/kg and 6.78mg/kg, respectively. These results indicate that intermittent REMSD treatment increases gastrointestinal transit; this model may be useful for evaluating the effects of drugs on diarrhea-predominant IBS, and the supersensitivity of peripheral , μ-opioid receptor may be involved in the accelerated gastrointestinal transit.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2006-12-01"}],"displaytype":"detail","filename":"KJ00004687277.pdf","filesize":[{"value":"616.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00004687277","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/191/files/KJ00004687277.pdf"},"version_id":"52311b0a-6143-4f9d-a1e8-af06af2b6243"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"REM sleep deprivation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gastrointestinal transit","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"irritable bowel syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diazepam","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"loperamide","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"断続的なREM断眠ストレス負荷誘発性マウス腸管輸送能の亢進","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"断続的なREM断眠ストレス負荷誘発性マウス腸管輸送能の亢進","subitem_title_language":"ja"},{"subitem_title":"Accelerated Gastrointestinal Transit Induced by Intermittent Rapid Eye Movement (REM) Sleep Deprivation Treatment in Mice","subitem_title_language":"en"}]},"item_type_id":"1","owner":"15","path":["9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2006-12-01"},"publish_date":"2006-12-01","publish_status":"0","recid":"191","relation_version_is_last":true,"title":["断続的なREM断眠ストレス負荷誘発性マウス腸管輸送能の亢進"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:50:57.659504+00:00"}