{"created":"2023-06-20T13:11:06.646956+00:00","id":140,"links":{},"metadata":{"_buckets":{"deposit":"de5d155f-cabf-4bd6-965d-b54e41d0f239"},"_deposit":{"created_by":15,"id":"140","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"140"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000140","sets":["3:11"]},"author_link":[],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"54","bibliographicPageEnd":"47","bibliographicPageStart":"33","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"瀧澤, 俊也","creatorNameLang":"ja"},{"creatorName":"タキザワ, トシヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Takizawa, Toshiya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"成田, 紘一","creatorNameLang":"ja"},{"creatorName":"ナリタ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Narita, Koichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"渡邉, 一弘","creatorNameLang":"ja"},{"creatorName":"ワタナベ, カズヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Kazuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"阿部, 秀樹","creatorNameLang":"ja"},{"creatorName":"アベ, ヒデキ","creatorNameLang":"ja-Kana"},{"creatorName":"Abe, Hideki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"加藤, 正","creatorNameLang":"ja"},{"creatorName":"カトウ, タダシ","creatorNameLang":"ja-Kana"},{"creatorName":"Katoh, Tadashi","creatorNameLang":"en"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"Spiruchostatin A (1), isolated from a culture broth of Pseudomonas sp., has been shown to be a potent histone deacetylase (HDAC) inhibitor. HDAC inhibitors can suppress the growth of human tumor xenografts, this natural product, therefore, is expected to be a promising candidate for novel molecular-targeted anticancer agents. We envisioned that 1 would be synthesized through twofold macrolactam/macrolactone cyclization of the fully elaborated acyclic disulfide 2. The key segments 3 and 4, required for the preparation of the advanced key intermediate 2, were initially synthesized, and the two segments were subsequently subjected to the critical cross S-S coupling reaction to produce the desired key intermediate 11 (synthetically equivalent to 2). Upon deprotection of the N-Boc and the methyl ester groups in 11, the crucial cyclization formation was achieved using PyBOP to provide the desired macrolactam 16, a potential key precursor for 1. Further investigations concerning the transformation of 16 to the target molecule 1 were also described.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2007-12-01"}],"displaytype":"detail","filename":"KJ00005384866.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00005384866","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/140/files/KJ00005384866.pdf"},"version_id":"435725e2-be0a-4d12-9c4d-9bf8fdc8db70"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"spiruchostatin A","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"histone deacetylase inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"disulfide bond formation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"macrolactam/macrolactone cyclization","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒストン脱アセチル化酵素阻害物質スピルコスタチンAの合成研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒストン脱アセチル化酵素阻害物質スピルコスタチンAの合成研究","subitem_title_language":"ja"},{"subitem_title":"Synthetic Studies on Spiruchostatin A, a Potent Histone Deacetylase Inhibitor","subitem_title_language":"en"}]},"item_type_id":"1","owner":"15","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-12-01"},"publish_date":"2007-12-01","publish_status":"0","recid":"140","relation_version_is_last":true,"title":["ヒストン脱アセチル化酵素阻害物質スピルコスタチンAの合成研究"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:47:42.139188+00:00"}