@article{oai:tohoku-mpu.repo.nii.ac.jp:00000140,
 author = {瀧澤, 俊也 and Takizawa, Toshiya and 成田, 紘一 and Narita, Koichi and 渡邉, 一弘 and Watanabe, Kazuhiro and 阿部, 秀樹 and Abe, Hideki and 加藤, 正 and Katoh, Tadashi},
 issue = {54},
 journal = {東北薬科大学研究誌, Journal of Tohoku Pharmaceutical University},
 month = {Dec},
 note = {Spiruchostatin A (1), isolated from a culture broth of Pseudomonas sp., has been shown to be a potent histone deacetylase (HDAC) inhibitor. HDAC inhibitors can suppress the growth of human tumor xenografts, this natural product, therefore, is expected to be a promising candidate for novel molecular-targeted anticancer agents. We envisioned that 1 would be synthesized through twofold macrolactam/macrolactone cyclization of the fully elaborated acyclic disulfide 2. The key segments 3 and 4, required for the preparation of the advanced key intermediate 2, were initially synthesized, and the two segments were subsequently subjected to the critical cross S-S coupling reaction to produce the desired key intermediate 11 (synthetically equivalent to 2). Upon deprotection of the N-Boc and the methyl ester groups in 11, the crucial cyclization formation was achieved using PyBOP to provide the desired macrolactam 16, a potential key precursor for 1. Further investigations concerning the transformation of 16 to the target molecule 1 were also described.},
 pages = {33--47},
 title = {ヒストン脱アセチル化酵素阻害物質スピルコスタチンAの合成研究},
 year = {2007},
 yomi = {タキザワ, トシヤ and ナリタ, コウイチ and ワタナベ, カズヒロ and アベ, ヒデキ and カトウ, タダシ}
}