{"created":"2023-06-20T13:11:05.866411+00:00","id":123,"links":{},"metadata":{"_buckets":{"deposit":"31266f67-19e4-45b4-941d-056abe91a503"},"_deposit":{"created_by":15,"id":"123","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"123"},"status":"published"},"_oai":{"id":"oai:tohoku-mpu.repo.nii.ac.jp:00000123","sets":["3:12"]},"author_link":[],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"55","bibliographicPageEnd":"90","bibliographicPageStart":"85","bibliographic_titles":[{"bibliographic_title":"東北薬科大学研究誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Tohoku Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小田, 彰史","creatorNameLang":"ja"},{"creatorName":"オダ, アキフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Oda, Akifumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"小林, 佳奈","creatorNameLang":"ja"},{"creatorName":"コバヤシ, カナ","creatorNameLang":"ja-Kana"},{"creatorName":"Kobayashi, Kana","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"高橋, 央宜","creatorNameLang":"ja"},{"creatorName":"タカハシ, オウギ","creatorNameLang":"ja-Kana"},{"creatorName":"Takahashi, Ohgi","creatorNameLang":"en"}]}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"In this study,we construct the three dimensional structure of Uridine Diphosphate Glucuronosyltransferate (UGT) 1A1 by using for template homology/analyogy recognition engine (phyre) server.Ten PDB entries including UGT2B7 were used for template of the model,and both UDP-glucuronic acid binding domain and substrate binding domain were obtained. By using the modeled structure,structural refinement was carried out by molecular dynamics (MD) simulations.In order to investigate the role of cysteine,MD simulations of both UGT1A1 models with and without the Cys127-Cys156 disulfide bond were performed.As the results of the simulations,structural features of UGT1A1 can be investigated, and refined structure of it was obtained.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1149311X","subitem_source_identifier_type":"NCID"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2008-12-01"}],"displaytype":"detail","filename":"KJ00007565879.pdf","filesize":[{"value":"918.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00007565879","objectType":"fulltext","url":"https://tohoku-mpu.repo.nii.ac.jp/record/123/files/KJ00007565879.pdf"},"version_id":"a0b2bb10-dcaf-4152-a2e8-324893455fc1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Uridine Diphosphate Glucuronosyltransferase;Structural Prediction;Drug Metabolism","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ウリジン二リン酸グルクロン酸転移酵素1A1の立体構造予測","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ウリジン二リン酸グルクロン酸転移酵素1A1の立体構造予測","subitem_title_language":"ja"},{"subitem_title":"Prediction of Three Dimensional Structure of Uridine Diphosphate Glucuronosyltransferate 1A1","subitem_title_language":"en"}]},"item_type_id":"1","owner":"15","path":["12"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-12-01"},"publish_date":"2008-12-01","publish_status":"0","recid":"123","relation_version_is_last":true,"title":["ウリジン二リン酸グルクロン酸転移酵素1A1の立体構造予測"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-03-03T23:47:40.700554+00:00"}