WEKO3
アイテム
アルデヒドオキシターゼの種差，個体差の解析
https://tohoku-mpu.repo.nii.ac.jp/records/731
https://tohoku-mpu.repo.nii.ac.jp/records/731a79f1816-b468-4f2f-bd78-f6064720d01c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
アルデヒドオキシターゼの種差，個体差の解析 (2.6 MB)
|
.png)
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2018-12-06 | |||||||||||
| タイトル | ||||||||||||
| タイトル | アルデヒドオキシターゼの種差，個体差の解析 | |||||||||||
| 言語 | ja | |||||||||||
| タイトル | ||||||||||||
| タイトル | Speices and Individual Difference of Aldehyde Oxidase | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | jpn | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | aldehyde oxidase | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | individual differences | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | strain differences | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | species differences | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | dimer formation | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| 著者 |
伊藤, 邦郎
× 伊藤, 邦郎
|
|||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Aldehyde oxidase（AO）is a major member of the xanthine oxidase family belonging to the class of complex molybdo-flavoenzymes and plays an important role in the nucleophilic oxidation of N-heterocyclic aromatic compounds as well as various aldehydes. AO is homodimers with a subunit molecular weight of about 150 kDa and exhibit catalytic activity only as a dimer. An AO subunit contains a molybdopterin cofactor, an FAD and two different 2Fe-2S redox centers. The enzyme catalyzes oxidation of a wide range of endogenous and exogenous aldehydes and N-heterocyclic aromatic compounds. The enzyme has been well known to show remarkable species differences. When the enzyme is focused on rabbit and monkey, the former showed extremely high activity towards cinchonidine and methotrxate but the latter exhibited only marginal activities. In contrast, monkey had several times greater activity than did rabbit towards zonisamide and（S）-RS-8359. In addition, marked differences in species, large differences in rat strains and individual differences of AO activities in some rat strains have been reported. However, little has been elucidated about any related molecular biological mechanisms. We examined the mechanism of individual variations, strain and species difference of AO using the technology of molecular biology. Our recent studies regarding the inter- and intra-species difference of Ao activities are described in this review. |
|||||||||||
| 言語 | en | |||||||||||
| 書誌情報 |
ja : 東北医科薬科大学研究誌 en : Journal of Tohoku Medical and Pharmaceutical University 号 64, p. 29-38, 発行日 2017-12 |
|||||||||||
| 出版者 | ||||||||||||
| 出版者 | 東北医科薬科大学 | |||||||||||
| 言語 | ja | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 2432-5724 | |||||||||||
| 権利 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by-nc-nd/3.0/deed.en | |||||||||||
| 権利情報 | Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
