WEKO3
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抗結核作用を有するベルチヘミプテリドA の合成研究:ビス-α-スルフェニルジケトピペラジン誘導体の合成
https://tohoku-mpu.repo.nii.ac.jp/records/566
https://tohoku-mpu.repo.nii.ac.jp/records/5667e70976c-d5d4-4022-a673-1b498d7653f6
名前 / ファイル | ライセンス | アクション |
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抗結核作用を有するベルチヘミプテリドA の合成研究:ビス-α-スルフェニルジケトピペラジン誘導体の合成 (1.3 MB)
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||||||||||||||||||||
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公開日 | 2014-07-29 | |||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||
タイトル | 抗結核作用を有するベルチヘミプテリドA の合成研究:ビス-α-スルフェニルジケトピペラジン誘導体の合成 | |||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
タイトル | Synthetic Studies on Vertihemiptellide A, a Potential Antituberculosis Agent:Synthesis of bis-α-Sulfenylated Diketopiperazine Derivative | |||||||||||||||||||||||
言語 | ||||||||||||||||||||||||
言語 | jpn | |||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||
主題 | vertihemiptellide A | |||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||
主題 | antituberculosis agent | |||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||
主題 | diketopiperazine dimer | |||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||
主題 | sulfenylation | |||||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
資源タイプ | departmental bulletin paper | |||||||||||||||||||||||
著者名 |
成田, 紘一
× 成田, 紘一
× 熱海, 秀
× 加藤, 正
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抄録 | ||||||||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||||||||
内容記述 | Bis-α-sulfenylated diketopiperazine derivative corresponding to the monomer of vertihemiptellide A, a potential antituberculosis agent from the insect pathogenic fungus Verticillium hemipterigenum BCC 1499, was synthesized. the method involved the following crucial steps: ⅰ)regioselective nucleophilic addition of Grignard reagent to a tricarbonyl compound; ⅱ)dihydroxylation of a diketopiperazine containing exo-methylene function using oso4 in the presence of phenylboronic acid and N-methylmorpholine N-oxide(NMo); and ⅲ)α-sulfenylation of a diketopiperazine derivative using 4-methoxybenzyl mercaptan(PMB-Sh)and trifluoroacetic acid(tFA). | |||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
書誌情報 |
ja : 東北薬科大学研究誌 en : Journal of Tohoku Pharmaceutical University 号 60, p. 55-63, 発行日 2013-12 |
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雑誌書誌ID | ||||||||||||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||||||||||||
収録物識別子 | AA1149311X |