| Item type |
紀要論文(ELS) / Departmental Bulletin Paper(1) |
| 公開日 |
2011-12-01 |
| タイトル |
|
|
タイトル |
RajiおよびK562細胞に対するナマズ卵レクチンと抗腫瘍薬との併用効果 |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
Combination Effect of Catfish Lectin and Anti-cancer Drugs on Raji and K562 Cells. |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Rhamnose-binding lectin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
globotriaosylceramide |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
anti-cancer drug |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者名 |
菅原, 栄紀
新谷, 香絵
細野, 雅祐
立田, 岳生
仁田, 一雄
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Silurus asotus(catfish)lectin(SAL)is a 32 kDa protein belonging to the rhamnose-binding lectin(RBL)family. SAL also recognizes galactosylα-linked carbohydrate chains of not only glycoproteins but also glycosphingolipids, especially globotriaosylceramide(Gb3). in the previous study, we revealed that SAL increased uptake of doxorubicin(Dox)into Raji cells, and consequently enhanced cytotoxic effect of Dox. we studied whether SAL also enhances the cytotoxic effect of vinblastine and irinotecan in Gb3-expressing Raji or Gb3-negative K562 cells. Treatment of Raji cells with vinblastine(2.5μg/mL)and irinotecan(5μM)for 48 h caused decrease of cell viability to 69% and 68%, respectively. although cytotoxic effects of vinblastine and irinotecan were significantly increased in SAL-pretreated Raji cells, only a slight increase was observed in SAL-pretreated K562 cells with vinblastine. These results indicate that SAL enhances the cytotoxic effect of vinblastine or irinotecan in raji but not K562 cells. |
|
言語 |
en |
| 書誌情報 |
ja : 東北薬科大学研究誌
en : Journal of Tohoku Pharmaceutical University
号 58,
p. 41-46,
発行日 2011-12
|
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1149311X |
KJ00008219399 (946.1 kB)
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