| Item type |
紀要論文(ELS) / Departmental Bulletin Paper(1) |
| 公開日 |
2005-12-01 |
| タイトル |
|
|
タイトル |
アレルギー性気道炎症における性ホルモンおよびリンパ球の役割 |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
The roles of lymphocytes and sex hormones in the pathogenesis of allergic airway inflammation |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
asthma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
sex differences |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
airway inflammation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lymphocytes |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者名 |
小松, 聡子
斉藤, 淳郎
堀田, 夏美
山ノ内, 美夏
大和田, 恵子
奥山, 香織
高柳, 元明
大野, 勲
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Epidemiological data indicate that the prevalence and severity of asthma is higher among females than males after puberty. The influence of sex on asthma incidence suggests that sex hormones could play a role in the pathogenesis of the condition associated with asthma. However, the mechanisms of the affect of sex are not clear. Therefore, in the current study, we investigated the sex differences in allergic inflammation in terms of lymphocyte function, using a murine model of allergic asthma. In either BALB/c or C57BL/6J mice, the airway inflammation in female mice sensitized with OVA followed by OVA inhalation was more severe than that in male mice. The contents of Th2 cytokines, such as IL-4, IL-5 and IL-13, in bronchoalveolar lavage fluid from female mice were significantly increased compared with male mice. The airway inflammation in female mice after adoptive transfer of splenocyte from sensitized female mice was more severe than that in any other combination of donors and recipients. Furthermore, splenocytes from sensitized female mice produced more Th2 cytokines than those from sensitized male mice, upon stimulation with OVA. The degree of airway inflammation induced by lipopolysaccharide inhalation was not significantly different between male and female mice. Our findings suggest that sex differences in allergic airway inflammation are due to those in not only sex hormones but also lymphocytes function. |
|
言語 |
en |
| 書誌情報 |
ja : 東北薬科大学研究誌
en : Journal of Tohoku Pharmaceutical University
号 52,
p. 111-124,
発行日 2005-12
|
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1149311X |
KJ00004373135 (1.5 MB)
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