| Item type |
紀要論文(ELS) / Departmental Bulletin Paper(1) |
| 公開日 |
2005-12-01 |
| タイトル |
|
|
タイトル |
亜鉛欠乏がラット肝薬物代謝酵素に及ぼす影響 |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
Effects of zinc deficiency on rat liver drug-metabolizing enzymes |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
zinc deficiency |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ADH |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
HSD |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
P450 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
testosterone |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
sex differences |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者名 |
庭田, 英明
丸山, 香
高田, 史子
飯塚, 幸澄
伊藤, 邦郎
田中, 頼久
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Zinc is an essential trace element that plays many important biological roles in the body. In clinical cases and experimental animals, zinc deficiency results in several unfavorable features including growth retardation, hypogonadism, rough skin, and general lethargy. Regarding drug-metabolizing enzymes, there have only been reports that zinc deficiency reduced the content of mRNA and protein of male-specific CYP3A2, CYP3A18 and CYP2C11, and increased the mRNA levels of female-specific CYP2C12 and CYP3A9. We investigated the effects of zinc deficiency on alcohol dehydrogenase (ADH), hydroxysteroid dehydrogenase (HSD) and cytochrome P450s in rats. Cytosolic ADH1 activity was lower in male rats than in female rats. The lower ADH1 activity in male rats was increased to the level of that in female rats by zinc deficiency. Microsomal 20β-HSD activity was detected at a high rate in male rats but was under the limit of quantification (LOQ) in female rats. The high 20β-HSD activity in male rats was decreased to below the LOQ by zinc deficiency. 7-Ethoxycoumarin O-deethylase activity was inhibited by chloramphenicol in female zinc deficiency rats, but not in female control rats and male rats, indicating the induction of CYP2B1 by zinc deficiency in female rats. The mechanisms of changes in enzyme activity in male rats will be discussed based on the impaired testosterone-hypothalamus-pituitary axis originated from hypogonadism caused by zinc deficiency. The mechanisms of CYP2B1 induction in female rats are still unknown. |
|
言語 |
en |
| 書誌情報 |
ja : 東北薬科大学研究誌
en : Journal of Tohoku Pharmaceutical University
号 52,
p. 85-97,
発行日 2005-12
|
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1149311X |
KJ00004373132 (1.3 MB)
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