{"_buckets": {"deposit": "bf4a2604-d549-4360-8abc-0c5f2f97f4eb"}, "_deposit": {"created_by": 15, "id": "192", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "192"}, "status": "published"}, "_oai": {"id": "oai:tohoku-mpu.repo.nii.ac.jp:00000192", "sets": ["9"]}, "author_link": [], "item_1_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "53", "bibliographicPageEnd": "76", "bibliographicPageStart": "71", "bibliographic_titles": [{"bibliographic_title": "東北薬科大学研究誌", "bibliographic_titleLang": "ja"}, {"bibliographic_title": "Journal of Tohoku Pharmaceutical University", "bibliographic_titleLang": "en"}]}]}, "item_1_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "中山, 大助", "creatorNameLang": "ja"}, {"creatorName": "ナカヤマ, ダイスケ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Nakayama, Daisuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "渡邉, 廣行", "creatorNameLang": "ja"}, {"creatorName": "ワタナベ, ヒロユキ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Watanabe, Hiroyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "藤村, 務", "creatorNameLang": "ja"}, {"creatorName": "フジムラ, ツトム", "creatorNameLang": "ja-Kana"}, {"creatorName": "Fujimura, Tsutomu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "櫻田, 忍", "creatorNameLang": "ja"}, {"creatorName": "サクラダ, シノブ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Sakurada, Shinobu", "creatorNameLang": "en"}]}]}, "item_1_description_11": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "We have previously reported that Tyr-D-Pro-Trp-Gly-NH_2 (D-Pro^2-Tyr-W-MIF-1) given spinally produces clearly a dose-dependent attenuation of the antinociception induced by Tyr-W-MIF-1 without affecting endomorphins- and[D-Ala^2, NMePhe^4, Gly(ol)^5]-enkephalin (DAMGO)-induced antinociception, and D-Pro^2-Tyr-W-MIF-1 at any doses used (0.025-1.2 nmol) does not show any antinociception or hyperalgesic effect by itself. In the present study, we found that D-Pro^2-Tyr-W-MIF-1 given supraspinally produced the antinociception, which is mediated by stimulation of μ-opioid receptors. D-Pro^2-Tyr-W-MIF-1 (0.5-16 nmol) given intracerebroventricularly (i.c.v.) produced an apparent dose-dependent antinociception. However, at the three highest doses (4, 8 or 16 nmol), there was a ceiling effect (about 30% MPE) where the increase in dose did not lead to a greater effect. The antinociception induced by D-Pro^2-Tyr-W-MIF-1 at a dose of 4 nmol was blocked by i.c.v. co-administration with the μ-opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH_2 (CTOP), but not by i.c.v. pretreatment with the μ_1-opioid receptor antagonist naloxonazine, the κ-opioid receptor antagonist, nor-binaltorphimine, or the δ-opioid receptor antagonist naltrindole. In contrast, the antinociception induced by DAMGO and Tyr-W-MIF-1 was blocked by i.c.v. co-administration with CTOP or by i.c.v. pretreatment with higher doses of naloxonazine, but not by pretreatment with nor-binaltorphimine or naltrindole. We propose that the antinociception induced by D-Pro^2-Tyr-W-MIF-1 and Tyr-W-MIF-1 is mediated by the stimulation of different subtypes of μ_2-opioid receptors.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1149311X", "subitem_source_identifier_type": "NCID"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2006-12-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004687278.pdf", "filesize": [{"value": "469.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 469600.0, "url": {"label": "KJ00004687278", "objectType": "fulltext", "url": "https://tohoku-mpu.repo.nii.ac.jp/record/192/files/KJ00004687278.pdf"}, "version_id": "6b7e4bbe-572d-44fe-9630-39c5d82a769f"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Antinociception", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "u-Opioid receptor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "D-Pro^2-Tyr-W-MIF-1", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tyr-W-MIF-1", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "DAMGO", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Tyr-Pro-Trp-Gly-NH_2(Tyr-W-MIF-1)analogであるTyr-D-Pro-Trp-Gly-NH_2の抗侵害作用におけるμオピオイド受容体の関与について", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Tyr-Pro-Trp-Gly-NH_2(Tyr-W-MIF-1)analogであるTyr-D-Pro-Trp-Gly-NH_2の抗侵害作用におけるμオピオイド受容体の関与について", "subitem_title_language": "ja"}, {"subitem_title": "Involvement of μ-opioid receptor on the antinociception induced by supraspinal administration of Tyr-D-Pro-Trp-Gly-NH_2", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "15", "path": ["9"], "permalink_uri": "https://tohoku-mpu.repo.nii.ac.jp/records/192", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2006-12-01"}, "publish_date": "2006-12-01", "publish_status": "0", "recid": "192", "relation": {}, "relation_version_is_last": true, "title": ["Tyr-Pro-Trp-Gly-NH_2(Tyr-W-MIF-1)analogであるTyr-D-Pro-Trp-Gly-NH_2の抗侵害作用におけるμオピオイド受容体の関与について"], "weko_shared_id": -1}
Tyr-Pro-Trp-Gly-NH_2(Tyr-W-MIF-1)analogであるTyr-D-Pro-Trp-Gly-NH_2の抗侵害作用におけるμオピオイド受容体の関与について
https://tohoku-mpu.repo.nii.ac.jp/records/192
https://tohoku-mpu.repo.nii.ac.jp/records/192