{"_buckets": {"deposit": "de5d155f-cabf-4bd6-965d-b54e41d0f239"}, "_deposit": {"created_by": 15, "id": "140", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "140"}, "status": "published"}, "_oai": {"id": "oai:tohoku-mpu.repo.nii.ac.jp:00000140", "sets": ["11"]}, "author_link": [], "item_1_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2007-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "54", "bibliographicPageEnd": "47", "bibliographicPageStart": "33", "bibliographic_titles": [{"bibliographic_title": "東北薬科大学研究誌", "bibliographic_titleLang": "ja"}, {"bibliographic_title": "Journal of Tohoku Pharmaceutical University", "bibliographic_titleLang": "en"}]}]}, "item_1_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "瀧澤, 俊也", "creatorNameLang": "ja"}, {"creatorName": "タキザワ, トシヤ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Takizawa, Toshiya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "成田, 紘一", "creatorNameLang": "ja"}, {"creatorName": "ナリタ, コウイチ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Narita, Koichi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "渡邉, 一弘", "creatorNameLang": "ja"}, {"creatorName": "ワタナベ, カズヒロ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Watanabe, Kazuhiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "阿部, 秀樹", "creatorNameLang": "ja"}, {"creatorName": "アベ, ヒデキ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Abe, Hideki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "加藤, 正", "creatorNameLang": "ja"}, {"creatorName": "カトウ, タダシ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Katoh, Tadashi", "creatorNameLang": "en"}]}]}, "item_1_description_11": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "Spiruchostatin A (1), isolated from a culture broth of Pseudomonas sp., has been shown to be a potent histone deacetylase (HDAC) inhibitor. HDAC inhibitors can suppress the growth of human tumor xenografts, this natural product, therefore, is expected to be a promising candidate for novel molecular-targeted anticancer agents. We envisioned that 1 would be synthesized through twofold macrolactam/macrolactone cyclization of the fully elaborated acyclic disulfide 2. The key segments 3 and 4, required for the preparation of the advanced key intermediate 2, were initially synthesized, and the two segments were subsequently subjected to the critical cross S-S coupling reaction to produce the desired key intermediate 11 (synthetically equivalent to 2). Upon deprotection of the N-Boc and the methyl ester groups in 11, the crucial cyclization formation was achieved using PyBOP to provide the desired macrolactam 16, a potential key precursor for 1. Further investigations concerning the transformation of 16 to the target molecule 1 were also described.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1149311X", "subitem_source_identifier_type": "NCID"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2007-12-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00005384866.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "KJ00005384866", "objectType": "fulltext", "url": "https://tohoku-mpu.repo.nii.ac.jp/record/140/files/KJ00005384866.pdf"}, "version_id": "435725e2-be0a-4d12-9c4d-9bf8fdc8db70"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "spiruchostatin A", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "histone deacetylase inhibitor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "disulfide bond formation", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "macrolactam/macrolactone cyclization", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "ヒストン脱アセチル化酵素阻害物質スピルコスタチンAの合成研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ヒストン脱アセチル化酵素阻害物質スピルコスタチンAの合成研究", "subitem_title_language": "ja"}, {"subitem_title": "Synthetic Studies on Spiruchostatin A, a Potent Histone Deacetylase Inhibitor", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "15", "path": ["11"], "permalink_uri": "https://tohoku-mpu.repo.nii.ac.jp/records/140", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-12-01"}, "publish_date": "2007-12-01", "publish_status": "0", "recid": "140", "relation": {}, "relation_version_is_last": true, "title": ["ヒストン脱アセチル化酵素阻害物質スピルコスタチンAの合成研究"], "weko_shared_id": -1}
ヒストン脱アセチル化酵素阻害物質スピルコスタチンAの合成研究
https://tohoku-mpu.repo.nii.ac.jp/records/140
https://tohoku-mpu.repo.nii.ac.jp/records/140